Hydrochloric Acid → 6-(Morpholine-4-carbonyl)nicotinic acid

HRID 2120548Notes

Reaction equation

HRID 2120548 reaction equation
[N:1]1([C:7]([C:9]2[CH:21]=[CH:20][C:12]([C:13]([O:15]C(C)(C)C)=[O:14])=[CH:11][N:10]=2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl>[N+](C)([O-])=O>[N:1]1([C:7]([C:9]2[CH:21]=[CH:20][C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 100857186-(Morpholine-4-carbonyl)nicotinic acid, t-butyl ester

Product 1

HCID 101055146-(Morpholine-4-carbonyl)nicotinic acid

Reagents, catalysts & solvents 1

HCID 6375NitromethaneSolvent

Procedure

In step c, the t-butyl ester functionality of (12) is hydrolyzed, with for example, HCl in nitromethane, to give the corresponding, 6-(morpholine-4-carbonyl)nicotinic acid (13).

Sources & evidence

ORD record
ord-d0d8d7a52ffd4975898d105e5f8e0949
Source dataset
uspto-grants-2004_02
Patent number
US06693072B2

Reaction notes

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