Hydrochloric Acid → 2,6-Diamino-4-pyrimidinepentanoic acid

HRID 2120652Notes

Reaction equation

HRID 2120652 reaction equation
C([O:3][C:4](=[O:17])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[N:14]=[C:13]([NH2:15])[N:12]=[C:11]([NH2:16])[CH:10]=1)C.[OH-].[Na+].Cl>C1COCC1.O>[NH2:15][C:13]1[N:12]=[C:11]([NH2:16])[CH:10]=[C:9]([CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:17])=[O:3])[N:14]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58765530HCID 58765530, compound

Product 1

HCID 234355042,6-Diamino-4-pyrimidinepentanoic acid

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

The ethyl ester 2-2 (190 mg, 0.8 mmol) in THF (10 mL) and water (10 mL) was treated with 1 N NaOH (1.6 mL, 1.6 mmol). After stirring at room temperature for 16 hours, the solution was neutralized with 1N HCl and then the solvents removed in vacuo. The residue, 2-3 was used as such in the next step.

Workup

  1. customthe solvents removed in vacuo

Sources & evidence

ORD record
ord-ee0218678b314774a5dc25d88e2ea7b4
Source dataset
uspto-grants-2004_02
Patent number
US06693101B2

Reaction notes

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