Hydrochloric Acid → HCID 9924144, compound

HRID 2120672Notes

Reaction equation

HRID 2120672 reaction equation
C([O:3][C:4](=[O:27])[CH2:5][CH:6]([C:21]1[CH:22]=[N:23][CH:24]=[N:25][CH:26]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][CH3:20])[N:14]=1)C.[OH-].[Na+].Cl>CO.O>[CH3:20][NH:19][C:15]1[N:14]=[C:13]([CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH:6]([C:21]2[CH:22]=[N:23][CH:24]=[N:25][CH:26]=2)[CH2:5][C:4]([OH:27])=[O:3])[CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58765551HCID 58765551, compound

Product 1

HCID 9924144HCID 9924144, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

To a solution of 6-13a (0.215 g, 0.580 mmol) in TBf/MeOH/H2O 3:1:1 (10 mL)) was added NaOH (1.16 mL of 1N solution in water, 1.16 mmol). After 30 minutes, the mixture was neutralized with HCl (1.16 mL of 1N solution in water, 1.16 mmol) and the solvents were evaporated. The residue chromatographed on silica gel (15% MeOH/CHCl3) to give 6-14a as a white solid.

Workup

  1. customthe solvents were evaporated
  2. customThe residue chromatographed on silica gel (15% MeOH/CHCl3)

Sources & evidence

ORD record
ord-b24ea1a1c89941489506a1e9edd3a0db
Source dataset
uspto-grants-2004_02
Patent number
US06693101B2

Reaction notes

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