反应详情

3-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-3-oxopropionic acid (36) (1.20 g; 4.41 mmol) is dissolved in methylene chloride (40 mL) at ambient temperature. 1,7-Diphenyl-4-aminoheptane hydrochloride (1) (1.61 g; 5.29 mmol), N,N-diisopropylethylamine (1.82 g; 14.1 mmol) and PyBOP (2.75 g; 5.29 mmol) are added sequentially. The reaction is stirred for 14 hours at room temperature, then concentrated under reduced pressure. The residue is purified via silica gel chromatography (40%→70% ethyl acetate in hexanes) affording the desired product as a solid. ESMS: MH− 522.4

1. concentrationconcentrated under reduced pressure
2. customThe residue is purified via silica gel chromatography (40%→70% ethyl acetate in hexanes)