Phthalimide → HCID 178506417, compound

HRID 2120926Notes

Reaction equation

HRID 2120926 reaction equation
[C:1]1(=O)[NH:5][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1.[Fe:19](Cl)Cl>C(OCC)(=O)C>[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[N:12]=[C:4]1[C:3]2[C:2](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:1](=[N:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[NH:5]1.[Fe+2:19]

Participants

5

Reactant 3

HCID 6809PhthalimideHCID 104392-AminopyridineHCID 24458Ferrous Chloride

Product 1

HCID 178506417HCID 178506417, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 100-mL round-bottom flask equipped with a nitrogen inlet and an internal fritted-glass filter is charged with phthalimide (2.94 g, 20.0 mmol) and ethyl acetate (50 mL). 2-Aminopyridine (3.77 g, 40.0 mmol, 2.1 eq.) and iron(II) chloride (2.54 g, 20.0 mmol) are added to the flask, and the mixture is stirred under nitrogen at room temperature for 1 h. The mixture is stirred at room temperature for 120 h, yielding a white precipitate.

Workup

  1. customA 100-mL round-bottom flask equipped with a nitrogen inlet
  2. filtrationan internal fritted-glass filter
  3. stirringThe mixture is stirred at room temperature for 120 h
  4. customyielding a white precipitate

Sources & evidence

ORD record
ord-202405715b29417bade115d45c5faff3
Source dataset
uspto-grants-2004_02
Patent number
US06693154B2

Reaction notes

Loading…