Sodium Methoxide → HCID 69892025, compound

HRID 2121273Notes

Reaction equation

HRID 2121273 reaction equation
C[O:2][C:3](=[O:34])[C@H:4]([CH2:30][CH2:31][S:32][CH3:33])[NH:5][C:6](=[O:29])[C:7]1[CH:12]=[CH:11][C:10]([CH:13]=[CH:14][C:15]2[CH:16]=[N:17][CH:18]=[CH:19][C:20]=2Cl)=[CH:9][C:8]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH3:28].[CH3:35][O-:36].[Na+:37]>CN(C=O)C>[Na+:37].[CH3:35][O:36][C:20]1[CH:19]=[CH:18][N:17]=[CH:16][C:15]=1[CH:14]=[CH:13][C:10]1[CH:11]=[CH:12][C:7]([C:6]([NH:5][C@H:4]([C:3]([O-:34])=[O:2])[CH2:30][CH2:31][S:32][CH3:33])=[O:29])=[C:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:28])[CH:9]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 69892484HCID 69892484, compound

Product 1

HCID 69892025HCID 69892025, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

N-[4-(2-(4-chloropyridin-3-yl)ethenyl)-2-(2-methylphenyl)benzoyl]methionine methyl ester, prepared as in Example 1040, (62 mg, 0.12 mmol) was dissolved in DMF (1 mL) and treated with NaOMe (0.5 M in MeOH, 1.25 mL, 0.63 mmol). After stirring 18 hours at ambient temperature, the reaction was evaporated and lyophilized from water to provide 68 mg of the title compound. MS m/e 477 (M+H)+.

Workup

  1. customthe reaction was evaporated

Sources & evidence

ORD record
ord-98db019d73b24569b60caa079e0a1262
Source dataset
uspto-grants-2004_02
Patent number
US06693123B2

Reaction notes

Loading…