1-Phenylpiperazine → HCID 23433062, compound

HRID 2121361Notes

Reaction equation

HRID 2121361 reaction equation
Cl[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:3]=1.[C:13]1([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([N:19]2[CH2:24][CH2:23][N:22]([C:2]3[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:3]=3)[CH2:21][CH2:20]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 70961-PhenylpiperazineHCID 2799611Ethyl 6-chloronicotinate

Product 1

HCID 23433062HCID 23433062, compoundYield 125.2%

Conditions

Temperature
100 °C

Procedure

A mixture of 3.72 g (0.02 mol) of ethyl 6-chloronicotinate and 6.44 g (0.04 mol) of N-phenylpiperazine was stirred at 100° C. for 1 hour. The reaction mixture was concentrated in vacuo. The residue was stirred with isopropanol. 7.8 g of a yellow solid were obtained.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. stirringThe residue was stirred with isopropanol

Sources & evidence

ORD record
ord-3cc143efec694cd5be7d9d8f26d10b01
Source dataset
uspto-grants-2004_02
Patent number
US06696437B1

Reaction notes

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