Oxalyl chloride → 2,2-diphenylpropanoyl Chloride

HRID 2121491Notes

Reaction equation

HRID 2121491 reaction equation
C(Cl)(=O)C([Cl:4])=O.[C:7]1([C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:17])[C:14](O)=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CN(C)C=O.ClCCl>[C:7]1([C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:17])[C:14]([Cl:4])=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 796762,2-Diphenylpropionic acid

Product 1

HCID 114479422,2-diphenylpropanoyl Chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
50 °C

Procedure

52.08 g (0.33 mol) oxalyl chloride is slowly added dropwise at 20° C. to a suspension of 25.0 g (0.11 mol) of 2,2-diphenylpropionic acid, 100 mL of dichloromethane, and 4 drops of dimethylformamide. It is stirred for 1 hour at 20° C. and 0.5 hour at 50° C. The solvent is distilled off and the residue remaining is used in the next step without any further purification.

Workup

  1. distillationThe solvent is distilled off
  2. customthe residue remaining is used in the next step without any further purification

Sources & evidence

ORD record
ord-0db60394bee74a1bbb5e1ee82b8c10c8
Source dataset
uspto-grants-2004_02
Patent number
US06696462B2

Reaction notes

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