N-Methylethylamine → N'-(4-{[3-(1,1-dimethylethyl)phenyl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylthiourea

HRID 2121830Notes

Reaction equation

HRID 2121830 reaction equation
[CH2:1]([NH:3][CH3:4])[CH3:2].[CH3:5][C:6]([C:9]1[CH:10]=[C:11]([O:15][C:16]2[CH:21]=[C:20]([CH3:22])[C:19]([N:23]=[C:24]=[S:25])=[CH:18][C:17]=2[CH3:26])[CH:12]=[CH:13][CH:14]=1)([CH3:8])[CH3:7]>O1CCCC1>[CH3:8][C:6]([C:9]1[CH:10]=[C:11]([O:15][C:16]2[C:17]([CH3:26])=[CH:18][C:19]([NH:23][C:24](=[S:25])[N:3]([CH2:1][CH3:2])[CH3:4])=[C:20]([CH3:22])[CH:21]=2)[CH:12]=[CH:13][CH:14]=1)([CH3:5])[CH3:7]

Participants

4

Reactant 2

HCID 12219N-MethylethylamineHCID 234343591-{[3-(1,1-Dimethylethyl)phenyl]oxy}-4-isothiocyanato-2,5-dimethylbenzene

Product 1

HCID 23434357N'-(4-{[3-(1,1-dimethylethyl)phenyl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylthiourea

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethylmethylamine (450 mg) is added dropwise to a solution of 1-{[3-(1,1-dimethylethyl)phenyl]oxy}-4-isothiocyanato-2,5-dimethylbenzene (1.9 g) in tetrahydrofuran (6 ml) at 0° C. The reaction mixture obtained is stirred at room temperature for 1 h and then concentrated and triturated with heptane. The title product is obtained in the form of a white precipitate.

Workup

  1. customThe reaction mixture obtained
  2. concentrationconcentrated
  3. customtriturated with heptane

Sources & evidence

ORD record
ord-2fa6ffdad032424b9775313ce19ac8d2
Source dataset
uspto-grants-2004_02
Patent number
US06696487B2

Reaction notes

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