反应详情

3-t-Butylphenol (7.5 g) and potassium carbonate (6.9 g) are added to a solution of 1-chloro-2,5-dimethyl-4-nitrobenzene (9.5 g) in dimethylformamide (60 ml) under an inert atmosphere. The reaction mixture obtained is refluxed for 5 h and then partitioned in a water/diisopropyl ether mixture. The organic phase is washed with a basic aqueous solution and then with water at pH 7. Drying over magnesium sulphate and then addition of carbon black, followed by filtration through Celite gives, after concentration, the title product.

1. customThe reaction mixture obtained
2. temperatureis refluxed for 5 h
3. custompartitioned in a water/diisopropyl ether mixture
4. washThe organic phase is washed with a basic aqueous solution
5. dry with materialDrying over magnesium sulphate
6. additionaddition of carbon black
7. filtrationfollowed by filtration through Celite
8. customgives
9. concentrationafter concentration