Dichloromethane → N-(3-fluoro-4-(2-(4-(morpholine-4-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(4-fluorophenyl)-2-oxo-3-azabicyclo[3.1.0]hexane-1-carboxamide

HRID 2122261Notes

Reaction equation

HRID 2122261 reaction equation
[CH3:28][CH2:29][N:30]=[C:31]=[N:32][CH2:33][CH2:34][CH2:35][N:36]([CH3:37])[CH3:38].[CH:39]([N:40]([CH2:41][CH3:42])[CH:43]([CH3:44])[CH3:45])([CH3:46])[CH3:47].[Cl:80][CH2:81][Cl:82].[F:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[C:9](=[O:17])[C:10]3([C:14](=[O:15])[OH:16])[CH2:11][CH:12]3[CH2:13]2)[cH:6][cH:7]1.[NH2:48][c:49]1[cH:50][c:51]([F:79])[c:52]([O:53][c:54]2[c:55]3[c:56]([n:57][cH:58][cH:59]2)[cH:60][c:61](-[c:63]2[cH:64][cH:65][c:66]([C:69](=[O:70])[N:71]4[CH2:72][CH2:73][O:74][CH2:75][CH2:76]4)[cH:67][cH:68]2)[s:62]3)[cH:77][cH:78]1.[OH:18][n:19]1[c:20]2[c:21]([cH:22][cH:23][cH:24][cH:25]2)[n:26][n:27]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[C:9](=[O:17])[C:10]3([C:14](=[O:16])[NH:48][c:49]4[cH:50][c:51]([F:79])[c:52]([O:53][c:54]5[c:55]6[c:56]([n:57][cH:58][cH:59]5)[cH:60][c:61](-[c:63]5[cH:64][cH:65][c:66]([C:69](=[O:70])[N:71]7[CH2:72][CH2:73][O:74][CH2:75][CH2:76]7)[cH:67][cH:68]5)[s:62]6)[cH:77][cH:78]4)[CH2:11][CH:12]3[CH2:13]2)[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 67347265(4-(7-(4-Amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)phenyl)(morpholino)methanoneHCID 673496483-(4-Fluorophenyl)-2-oxo-3-azabicyclo[3.1.0]hexane-1-carboxylic acid

Product 1

HCID 67349638N-(3-fluoro-4-(2-(4-(morpholine-4-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(4-fluorophenyl)-2-oxo-3-azabicyclo[3.1.0]hexane-1-carboxamide

Sources & evidence

ORD record
ord-84f06f9ada3d4f5fbf9e7e49fa33db1b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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