Bromide ion → 6-chloro-4-phenyl-3-(2,2,2-trifluoroethyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one
Reaction equation
[Br-:34].[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][C:7](=[O:12])[N:6]([CH2:13][C:14]([F:15])([F:16])[F:17])[C:5]2([C:18]([F:19])([F:20])[F:21])[OH:22].[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1.[S:30]([Cl:31])([Cl:32])=[O:33].[c:35]1([Mg+:41])[cH:36][cH:37][cH:38][cH:39][cH:40]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][C:7](=[O:12])[N:6]([CH2:13][C:14]([F:15])([F:16])[F:17])[C:5]2([C:18]([F:19])([F:20])[F:21])[c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-c58c6f181c87402bbc4114c59e78637c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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