Hydrochloric Acid → Tert-butyl 4-(2-chloro-4-(picolinamido)phenyl)piperazine-1-carboxylate

HRID 2124956Notes

Reaction equation

HRID 2124956 reaction equation
[CH3:11][CH2:12][N:13]([CH2:14][CH3:15])[CH2:16][CH3:17].[Cl:39][CH2:40][Cl:41].[ClH:1].[NH2:18][c:19]1[cH:20][c:21]([Cl:38])[c:22]([N:25]2[CH2:26][CH2:27][N:28]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:29][CH2:30]2)[cH:23][cH:24]1.[n:2]1[c:3]([C:8](=[O:9])[Cl:10])[cH:4][cH:5][cH:6][cH:7]1>>[n:2]1[c:3]([C:8](=[O:9])[NH:18][c:19]2[cH:20][c:21]([Cl:38])[c:22]([N:25]3[CH2:26][CH2:27][N:28]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:29][CH2:30]3)[cH:23][cH:24]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 8471TriethylamineHCID 135034Pyridine-2-carbonyl chlorideHCID 18783766Tert-Butyl 4-(4-Amino-2-Chlorophenyl)Piperazine-1-Carboxylate

Product 1

HCID 67441071Tert-butyl 4-(2-chloro-4-(picolinamido)phenyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-d7f69e4a2fef4b26841ee4d7f3d44a06
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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