Hydroxide → 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-fluorophenyl)-2-pyrimidinamine

HRID 2125375Notes

Reaction equation

HRID 2125375 reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[F:1][C:2]([F:3])([F:4])[C:35]([NH:5][c:6]1[cH:7][c:8](-[c:12]2[n:13][n:14]3[c:15]([cH:16][cH:17][cH:18][cH:19]3)[c:20]2-[c:21]2[n:22][c:23]([NH:27][c:28]3[cH:29][c:30]([F:34])[cH:31][cH:32][cH:33]3)[n:24][cH:25][cH:26]2)[cH:9][cH:10][cH:11]1)=[O:36].[Li+:37].[OH-:38].[OH2:44]>>[NH2:5][c:6]1[cH:7][c:8](-[c:12]2[n:13][n:14]3[c:15]([cH:16][cH:17][cH:18][cH:19]3)[c:20]2-[c:21]2[n:22][c:23]([NH:27][c:28]3[cH:29][c:30]([F:34])[cH:31][cH:32][cH:33]3)[n:24][cH:25][cH:26]2)[cH:9][cH:10][cH:11]1

Participants

6

Reactant 5

HCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 595138292,2,2-Trifluoro-N-[3-(3-{2-[(3-fluorophenyl)amino]-4-pyrimidinyl}pyrazolo-[1,5-a]pyridin-2-yl)phenyl]acetamide

Product 1

HCID 595114034-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-fluorophenyl)-2-pyrimidinamine

Sources & evidence

ORD record
ord-c0a7a69bc1874dc59c745e17173f5959
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…