Tetrahydrofuran → Ethyl 2,2-difluoro-3-[4-(5-fluoropyridin-2-yl)phenyl]-3-hydroxybutanoate
Reaction equation
[Br:1][C:2]([C:3](=[O:4])[O:5][CH2:6][CH3:7])([F:8])[F:9].[F:10][c:11]1[cH:12][cH:13][c:14](-[c:17]2[cH:18][cH:19][c:20]([C:23]([CH3:24])=[O:25])[cH:21][cH:22]2)[n:15][cH:16]1.[I-:26].[I-:27].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1.[Sm+2:28]>>[C:2]([C:3](=[O:4])[O:5][CH2:6][CH3:7])([F:8])([F:9])[C:23]([c:20]1[cH:19][cH:18][c:17](-[c:14]2[cH:13][cH:12][c:11]([F:10])[cH:16][n:15]2)[cH:22][cH:21]1)([CH3:24])[OH:25]Participants
6
Sources & evidence
- ORD record
- ord-397cba4ed73c4c488230f3f1c8660713
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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