Dimethylformamide → [3',5'-Dichloro-4'-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-yloxy]-acetic acid ethyl ester

HRID 2125644Notes

Reaction equation

HRID 2125644 reaction equation
[Br:29][CH2:30][C:31](=[O:32])[O:33][CH2:34][CH3:35].[CH:1]1([N:7]2[C:8](=[O:28])[CH:9]([CH2:12][c:13]3[c:14]([Cl:27])[cH:15][c:16](-[c:20]4[cH:21][cH:22][c:23]([OH:26])[cH:24][cH:25]4)[cH:17][c:18]3[Cl:19])[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[Cl:37][c:38]1[cH:39][c:40](-[c:41]2[cH:42][cH:43][c:44]([C:45]([OH:46])=[O:47])[cH:48][cH:49]2)[cH:50][cH:51][c:52]1[CH2:53][CH:54]1[CH2:55][CH2:56][N:57]([CH:58]2[CH2:59][CH2:60][CH2:61][CH2:62][CH2:63]2)[C:64]1=[O:65].[Na:36].[O:66]=[CH:67][N:68]([CH3:69])[CH3:70]>>[CH:1]1([N:7]2[C:8](=[O:28])[CH:9]([CH2:12][c:13]3[c:14]([Cl:27])[cH:15][c:16](-[c:20]4[cH:21][cH:22][c:23]([O:26][CH2:30][C:31](=[O:32])[O:33][CH2:34][CH3:35])[cH:24][cH:25]4)[cH:17][c:18]3[Cl:19])[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 7748Ethyl bromoacetateHCID 5360545SodiumHCID 592993351-Cyclohexyl-3-(3,5-dichloro-4'-hydroxy-biphenyl-4-ylmethyl)-pyrrolidin-2-oneHCID 592994614-[3-Chloro-4-[(1-cyclohexyl-2-oxopyrrolidin-3-yl)methyl]phenyl]benzoic acid

Product 1

HCID 11569665[3',5'-Dichloro-4'-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-yloxy]-acetic acid ethyl ester

Sources & evidence

ORD record
ord-0c13d05a51bb47049b77231e0ca00dd4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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