Isopropyl Acetate → 3-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione
Reaction equation
[C:48]([O:49][CH:50]([CH3:51])[CH3:52])(=[O:53])[CH3:54].[CH3:38][Si:39]([CH3:40])([CH3:41])[N-:42][Si:43]([CH3:44])([CH3:45])[CH3:46].[Cl:1][c:2]1[c:3]([F:23])[c:4](=[O:22])[n:5]([CH3:21])[c:6]2[n:7][cH:8][n:9]([CH2:13][CH:14]3[O:15][C:16]([CH3:19])([CH3:20])[O:17][CH2:18]3)[c:10](=[O:12])[c:11]12.[F:24][c:25]1[c:26]([NH2:27])[cH:28][cH:29][c:30]([I:32])[cH:31]1.[Li+:47].[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1>>[c:2]1([NH:27][c:26]2[c:25]([F:24])[cH:31][c:30]([I:32])[cH:29][cH:28]2)[c:3]([F:23])[c:4](=[O:22])[n:5]([CH3:21])[c:6]2[n:7][cH:8][n:9]([CH2:13][CH:14]3[O:15][C:16]([CH3:19])([CH3:20])[O:17][CH2:18]3)[c:10](=[O:12])[c:11]12Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-e5a03a2f3be745c48baa41005057a9a8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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