Dichloromethane → 7-Chloro-2-(3-cyclohexylpropionyl)-6-phenyl-1,2,3,4-tetrahydropyrrolo [1,2-a]pyrazine-8-carboxylic acid amide

HRID 2125956Notes

Reaction equation

HRID 2125956 reaction equation
[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[CH:34]1([CH2:40][CH2:41][C:42](=[O:43])[Cl:44])[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]1.[Cl:45][CH2:46][Cl:47].[Cl:8][c:9]1[c:10]([C:24](=[O:25])[NH2:26])[c:11]2[n:12]([c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH2:13][CH2:14][NH:15][CH2:16]2.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[Cl:8][c:9]1[c:10]([C:24](=[O:25])[NH2:26])[c:11]2[n:12]([c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH2:13][CH2:14][N:15]([C:42]([CH2:41][CH2:40][CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]1)=[O:43])[CH2:16]2

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 2734098Cyclohexylpropionyl chlorideHCID 68886671HCID 68886671, compound

Product 1

HCID 587619987-Chloro-2-(3-cyclohexylpropionyl)-6-phenyl-1,2,3,4-tetrahydropyrrolo [1,2-a]pyrazine-8-carboxylic acid amide

Sources & evidence

ORD record
ord-f54dbbf8735b4c7f945710934275f05f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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