Tetrahydrofuran → 3-(Pyrimidin-2-yl)-2,2-bis(3-(trifluoromethoxy)phenyl)propanoic acid
Reaction equation
[Br:32][CH2:33][c:34]1[n:35][cH:36][cH:37][cH:38][n:39]1.[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:27][CH2:28][CH2:29][CH2:30][Li:31].[F:1][C:2]([O:3][c:4]1[cH:5][c:6]([CH:10]([C:11](=[O:12])[OH:13])[c:14]2[cH:15][c:16]([O:20][C:21]([F:22])([F:23])[F:24])[cH:17][cH:18][cH:19]2)[cH:7][cH:8][cH:9]1)([F:25])[F:26]>>[F:1][C:2]([O:3][c:4]1[cH:5][c:6]([C:10]([C:11](=[O:12])[OH:13])([c:14]2[cH:15][c:16]([O:20][C:21]([F:22])([F:23])[F:24])[cH:17][cH:18][cH:19]2)[CH2:33][c:34]2[n:35][cH:36][cH:37][cH:38][n:39]2)[cH:7][cH:8][cH:9]1)([F:25])[F:26]Participants
5
Sources & evidence
- ORD record
- ord-6b1e513efaff493a9b7f881df0048a38
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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