Tetrahydrofuran → 2-(2-cyclopentyl-5,6,7,8-tetrahydro-indolizin-3-yl)-N-{4-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-acetamide

HRID 2129578Notes

Reaction equation

HRID 2129578 reaction equation
[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[CH3:1][c:2]1[cH:3][c:4]([N:9]2[CH2:10][CH2:11][N:12]([c:15]3[cH:16][cH:17][c:18]([NH2:21])[cH:19][cH:20]3)[CH2:13][CH2:14]2)[n:5][c:6]([CH3:8])[cH:7]1.[CH3:22][CH2:23][N:24]([CH2:25][CH3:26])[CH2:27][CH3:28].[CH:29]1([c:34]2[cH:35][c:36]3[n:41]([c:42]2[C:43]([C:44](=[O:45])[Cl:46])=[O:47])[CH2:40][CH2:39][CH2:38][CH2:37]3)[CH2:30][CH2:31][CH2:32][CH2:33]1>>[CH3:1][c:2]1[cH:3][c:4]([N:9]2[CH2:10][CH2:11][N:12]([c:15]3[cH:16][cH:17][c:18]([NH:21][C:44]([C:43]([c:42]4[c:34]([CH:29]5[CH2:30][CH2:31][CH2:32][CH2:33]5)[cH:35][c:36]5[n:41]4[CH2:40][CH2:39][CH2:38][CH2:37]5)=[O:47])=[O:45])[cH:19][cH:20]3)[CH2:13][CH2:14]2)[n:5][c:6]([CH3:8])[cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 668513514-[4-(4,6-Dimethyl-2-pyridyl)piperazin-1-yl]anilineHCID 86649693HCID 86649693, compound

Product 1

HCID 251220302-(2-cyclopentyl-5,6,7,8-tetrahydro-indolizin-3-yl)-N-{4-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-acetamide

Sources & evidence

ORD record
ord-2480ed4a56aa49cda7ef8b2f9d53ab95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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