Dimethylformamide → 1-(2-Naphthylmethyl)-2-oxo-4-[1-(4-pyridyl)piperidin-4-ylcarbonyl]-piperazine

HRID 213008Notes

Reaction equation

HRID 213008 reaction equation
[F:16][C:17]([F:18])([F:19])[C:20]([OH:21])=[O:22].[O:41]=[CH:42][N:43]([CH3:44])[CH3:45].[cH:23]1[c:24]([CH2:33][N:34]2[C:35](=[O:40])[CH2:36][NH:37][CH2:38][CH2:39]2)[cH:25][cH:26][c:27]2[cH:28][cH:29][cH:30][cH:31][c:32]12.[n:1]1[cH:2][cH:3][c:4]([N:7]2[CH2:8][CH2:9][CH:10]([C:13](=[O:14])[Cl:15])[CH2:11][CH2:12]2)[cH:5][cH:6]1>>[n:1]1[cH:2][cH:3][c:4]([N:7]2[CH2:8][CH2:9][CH:10]([C:13](=[O:14])[N:37]3[CH2:36][C:35](=[O:40])[N:34]([CH2:33][c:24]4[cH:23][c:32]5[c:27]([cH:26][cH:25]4)[cH:28][cH:29][cH:30][cH:31]5)[CH2:39][CH2:38]3)[CH2:11][CH2:12]2)[cH:5][cH:6]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6422Trifluoroacetic acidHCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chlorideHCID 227218301-(Naphthalen-2-ylmethyl)piperazin-2-one

Product 1

HCID 227217781-(2-Naphthylmethyl)-2-oxo-4-[1-(4-pyridyl)piperidin-4-ylcarbonyl]-piperazine

Sources & evidence

ORD record
ord-61ede203bb6140c4adea2426949b98aa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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