Toluene → 3-Bromo-5-((tetrahydro-2H-pyran-4-yl)oxy)pyridine

HRID 2131262Notes

Reaction equation

HRID 2131262 reaction equation
[Br:1][c:2]1[cH:3][c:4]([OH:8])[cH:5][n:6][cH:7]1.[CH3:47][c:48]1[cH:49][cH:50][cH:51][cH:52][cH:53]1.[O:28]1[CH2:29][CH2:30][CH:31]([OH:34])[CH2:32][CH2:33]1.[O:35]=[C:36]([O:37][CH2:38][CH3:39])[N:40]=[N:41][C:42]([O:43][CH2:44][CH3:45])=[O:46].[c:9]1([P:10]([c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)[c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[cH:23][cH:24][cH:25][cH:26][cH:27]1>>[Br:1][c:2]1[cH:3][c:4]([O:8][CH:31]2[CH2:30][CH2:29][O:28][CH2:33][CH2:32]2)[cH:5][n:6][cH:7]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 11776TriphenylphosphineHCID 74956Tetrahydro-4H-pyran-4-olHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 5995293-Bromo-5-hydroxypyridine

Product 1

HCID 219640263-Bromo-5-((tetrahydro-2H-pyran-4-yl)oxy)pyridine

Sources & evidence

ORD record
ord-058778131d6d42c4baf3a70b9224378e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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