Tetrahydrofuran → 1,1-Dimethylethyl 4-(3-cyanophenyl)-4-hydroxy-1-piperidinecarboxylate
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:5]#[N:6])[cH:7][cH:8][cH:9]1.[C:15](=[O:16])([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[N:22]1[CH2:23][CH2:24][C:25](=[O:28])[CH2:26][CH2:27]1.[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:10][CH2:11][CH2:12][CH2:13][Li:14]>>[c:2]1([C:25]2([OH:28])[CH2:24][CH2:23][N:22]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:27][CH2:26]2)[cH:3][c:4]([C:5]#[N:6])[cH:7][cH:8][cH:9]1Participants
5
Sources & evidence
- ORD record
- ord-bac8108489544a408b29d019cc86197e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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