Tetrahydrofuran → Tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(5-fluoro-6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperazine-1-carboxylate
Reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]([c:9]2[n:10][c:11](-[c:16]3[cH:17][c:18]([CH2:23][N:24]4[CH2:25][CH2:26][N:27]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:28][CH2:29]4)[cH:19][n:20][c:21]3[F:22])[n:12][c:13]([CH3:15])[n:14]2)[CH2:37][c:38]2[cH:39][cH:40][c:41]([O:44][CH3:45])[cH:42][cH:43]2)[cH:46][cH:47]1.[CH3:63][Si:64]([N-:65][Si:66]([CH3:67])([CH3:68])[CH3:69])([CH3:70])[CH3:71].[F:48][c:49]1[cH:50][c:51]([NH2:57])[cH:52][n:53][c:54]1[O:55][CH3:56].[Li+:72].[O:58]1[CH2:59][CH2:60][CH2:61][CH2:62]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]([c:9]2[n:10][c:11](-[c:16]3[cH:17][c:18]([CH2:23][N:24]4[CH2:25][CH2:26][N:27]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:28][CH2:29]4)[cH:19][n:20][c:21]3[NH:57][c:51]3[cH:50][c:49]([F:48])[c:54]([O:55][CH3:56])[n:53][cH:52]3)[n:12][c:13]([CH3:15])[n:14]2)[CH2:37][c:38]2[cH:39][cH:40][c:41]([O:44][CH3:45])[cH:42][cH:43]2)[cH:46][cH:47]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-9d77b07458614a0c83f4c13ed7b67fef
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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