Hydrochloric Acid → 2-(4-acetamidobenzenesulphonyl)-3,6-dihydro-6-(4-ethoxyphenyl)-3-hydroxymethyl-5-methyl-2H-1,2-oxazine

HRID 2132402Notes

Reaction equation

HRID 2132402 reaction equation
[C:27]([CH3:28])(=[O:29])[NH:30][c:31]1[cH:32][cH:33][c:34]([S:35](=[O:36])(=[O:37])[Cl:38])[cH:39][cH:40]1.[CH2:2]([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([CH:11]2[C:12]([CH3:19])=[CH:13][CH:14]([CH2:17][OH:18])[NH:15][O:16]2)[cH:9][cH:10]1.[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[CH2:25][CH3:26].[Cl:41][CH2:42][Cl:43].[ClH:1]>>[CH2:2]([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([CH:11]2[C:12]([CH3:19])=[CH:13][CH:14]([CH2:17][OH:18])[N:15]([S:35]([c:34]3[cH:33][cH:32][c:31]([NH:30][C:27]([CH3:28])=[O:29])[cH:40][cH:39]3)(=[O:36])=[O:37])[O:16]2)[cH:9][cH:10]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 8471TriethylamineHCID 8481N-Acetylsulfanilyl chlorideHCID 18401553[6-(4-ethoxyphenyl)-5-methyl-3,6-dihydro-2H-oxazin-3-yl]methanol

Product 1

HCID 184015412-(4-acetamidobenzenesulphonyl)-3,6-dihydro-6-(4-ethoxyphenyl)-3-hydroxymethyl-5-methyl-2H-1,2-oxazine

Sources & evidence

ORD record
ord-fbed586b99614d92b8a5f5713fa30164
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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