Water → 6-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)nicotinonitrile
Reaction equation
[Br:1][c:2]1[n:3][cH:4][c:5]([C:6]#[N:7])[cH:8][cH:9]1.[CH2:10]([Li:11])[CH2:12][CH2:13][CH3:14].[CH2:15]1[CH2:16][O:17][C:18]2([CH2:19][CH2:20][C:21](=[O:24])[CH2:22][CH2:23]2)[O:25]1.[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37].[OH2:26]>>[c:2]1([C:21]2([OH:24])[CH2:20][CH2:19][C:18]3([O:17][CH2:16][CH2:15][O:25]3)[CH2:23][CH2:22]2)[n:3][cH:4][c:5]([C:6]#[N:7])[cH:8][cH:9]1Participants
7
Sources & evidence
- ORD record
- ord-826af6a36ea24b97af25162052fc0eb1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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