Dichloromethane → [5-(4-Chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone

HRID 2133287Notes

Reaction equation

[CH2:47]([Cl:48])[Cl:49].[CH3:33][N:34]1[CH2:35][CH2:36][NH:37][CH2:38][CH2:39]1.[CH3:40][CH2:41][N:42]([CH2:43][CH3:44])[CH2:45][CH3:46].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([CH2:27][CH:28]3[CH2:29][CH2:30][CH2:31][CH2:32]3)[N:10]=[C:11]([c:16]3[c:17]([O:24][CH2:25][CH3:26])[cH:18][c:19]([O:22][CH3:23])[cH:20][cH:21]3)[N:12]2[C:13](=[O:14])[Cl:15])[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([CH2:27][CH:28]3[CH2:29][CH2:30][CH2:31][CH2:32]3)[N:10]=[C:11]([c:16]3[c:17]([O:24][CH2:25][CH3:26])[cH:18][c:19]([O:22][CH3:23])[cH:20][cH:21]3)[N:12]2[C:13](=[O:14])[N:37]2[CH2:36][CH2:35][N:34]([CH3:33])[CH2:39][CH2:38]2)[cH:6][cH:7]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 8471Triethylamine

HCID 531671-Methylpiperazine

HCID 218968915-(4-Chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride

Product 1

HCID 11193096[5-(4-Chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone

Sources & evidence

ORD record: ord-c9cf8f11125f47dd91ae68d0504f1fb2
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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