4-Toluenesulfonyl chloride → N-[4-({3-Bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)-3,5-difluorophenyl]acetamide
Reaction equation
[Br:1][c:2]1[cH:3][nH:4][c:5]2[n:6][cH:7][cH:8][c:9]([O:11][c:12]3[c:13]([F:23])[cH:14][c:15]([NH:19][C:20]([CH3:21])=[O:22])[cH:16][c:17]3[F:18])[c:10]12.[CH2:24]([Li:25])[CH2:26][CH2:27][CH3:28].[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[c:29]1([CH3:39])[cH:30][cH:31][c:32]([S:35](=[O:36])(=[O:37])[Cl:38])[cH:33][cH:34]1>>[Br:1][c:2]1[cH:3][n:4]([S:35]([c:32]2[cH:31][cH:30][c:29]([CH3:39])[cH:34][cH:33]2)(=[O:36])=[O:37])[c:5]2[n:6][cH:7][cH:8][c:9]([O:11][c:12]3[c:13]([F:23])[cH:14][c:15]([NH:19][C:20]([CH3:21])=[O:22])[cH:16][c:17]3[F:18])[c:10]12Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-e211821826544ed982a0a813f3ca324d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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