Hydrochloric Acid → 2,6-Dichloro-5-fluoronicotinic acid

HRID 2134933Notes

Reaction equation

HRID 2134933 reaction equation
[Cl:1][c:2]1[c:3]([C:4](=[O:5])[O:6][CH2:7][CH3:8])[cH:9][c:10]([F:14])[c:11]([Cl:13])[n:12]1.[ClH:22].[F:15][C:16]([F:17])([F:18])[C:19]([OH:20])=[O:21]>>[Cl:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[cH:9][c:10]([F:14])[c:11]([Cl:13])[n:12]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 13210747Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate

Product 1

HCID 27336592,6-Dichloro-5-fluoronicotinic acid

Sources & evidence

ORD record
ord-8cbde84bda0a4a7a929207271551f7e8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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