Dimethylformamide → 4-Benzyl-3-[3-[4-[[4-bromo-3-(trifluoromethoxy)phenyl]methoxy]phenyl]-3-(1,2-oxazol-3-yl)propanoyl]-1,3-oxazolidin-2-one

HRID 2135296Notes

Reaction equation

HRID 2135296 reaction equation
[Br:1][c:2]1[c:3]([O:10][C:11]([F:12])([F:13])[F:14])[cH:4][c:5]([CH2:8][OH:9])[cH:6][cH:7]1.[C:48](=[O:49])([O-:50])[O-:51].[CH2:19]([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[CH:26]1[N:27]([C:32]([CH2:33][CH:34]([c:35]2[n:36][o:37][cH:38][cH:39]2)[c:40]2[cH:41][cH:42][c:43]([OH:46])[cH:44][cH:45]2)=[O:47])[C:28](=[O:31])[O:29][CH2:30]1.[CH3:62][CH2:63][O:64][C:65]([CH3:66])=[O:67].[Cl:54][CH2:55][Cl:56].[Cs+:52].[Cs+:53].[O:57]=[CH:58][N:59]([CH3:60])[CH3:61].[S:15]([Br:16])([Br:17])=[O:18]>>[Br:1][c:2]1[c:3]([O:10][C:11]([F:12])([F:13])[F:14])[cH:4][c:5]([CH2:8][O:9][c:43]2[cH:42][cH:41][c:40]([CH:34]([CH2:33][C:32]([N:27]3[CH:26]([CH2:19][c:20]4[cH:21][cH:22][cH:23][cH:24][cH:25]4)[CH2:30][O:29][C:28]3=[O:31])=[O:47])[c:35]3[n:36][o:37][cH:38][cH:39]3)[cH:45][cH:44]2)[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 68176Thionyl bromideHCID 104967Cesium cation2×HCID 54472733(4-Bromo-3-(trifluoromethoxy)phenyl)methanolHCID 673300404-Benzyl-3-[3-(4-hydroxyphenyl)-3-(1,2-oxazol-3-yl)propanoyl]-1,3-oxazolidin-2-one

Product 1

HCID 673308694-Benzyl-3-[3-[4-[[4-bromo-3-(trifluoromethoxy)phenyl]methoxy]phenyl]-3-(1,2-oxazol-3-yl)propanoyl]-1,3-oxazolidin-2-one

Sources & evidence

ORD record
ord-4bef67d5b7b64ec6a3be172060c4bf10
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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