Dimethylformamide → Phenylmethyl 3-hydroxy-4-({[6-(1H-indol-4-yl)-1H-indazol-4-yl]amino}carbonyl)-1-pyrrolidinecarboxylate

HRID 2135309Notes

Reaction equation

HRID 2135309 reaction equation
[CH:63]([N:64]([CH2:65][CH3:66])[CH:67]([CH3:68])[CH3:69])([CH3:70])[CH3:71].[O:72]=[CH:73][N:74]([CH3:75])[CH3:76].[OH:1][CH:2]1[CH:3]([C:17](=[O:18])[OH:19])[CH2:4][N:5]([C:7](=[O:8])[O:9][CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)[CH2:6]1.[P-:20]([F:21])([F:22])([F:23])([F:24])([F:25])[F:26].[n:27]1([O:28][C:29]([N:30]([CH3:31])[CH3:32])=[N+:33]([CH3:34])[CH3:35])[c:36]2[n:37][cH:38][cH:39][cH:40][c:41]2[n:42][n:43]1.[nH:44]1[cH:45][cH:46][c:47]2[c:48](-[c:53]3[cH:54][c:55]([NH2:62])[c:56]4[cH:57][n:58][nH:59][c:60]4[cH:61]3)[cH:49][cH:50][cH:51][c:52]12>>[OH:1][CH:2]1[CH:3]([C:17](=[O:19])[NH:62][c:55]2[cH:54][c:53](-[c:48]3[c:47]4[cH:46][cH:45][nH:44][c:52]4[cH:51][cH:50][cH:49]3)[cH:61][c:60]3[c:56]2[cH:57][n:58][nH:59]3)[CH2:4][N:5]([C:7](=[O:8])[O:9][CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)[CH2:6]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 448909181-N-Cbz-4-hydroxy-beta-prolineHCID 582680196-(1H-indol-4-yl)-1H-indazol-4-amine

Product 1

HCID 44540587Phenylmethyl 3-hydroxy-4-({[6-(1H-indol-4-yl)-1H-indazol-4-yl]amino}carbonyl)-1-pyrrolidinecarboxylate

Sources & evidence

ORD record
ord-b459bdfe57b348bc951a37e9c31b0504
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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