Tetrahydrofuran → 3-[5-(2,4-Dimethyl-thiazol-5-yl)-3-methyl-thiophen-2-yl]-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine

HRID 2135934Notes

Reaction equation

HRID 2135934 reaction equation
[Br:19][c:20]1[cH:21][c:22]([CH3:41])[c:23](-[c:25]2[c:26]([CH3:40])[n:27][c:28]3[n:29]2[n:30][c:31]([CH3:39])[cH:32][c:33]3[CH:34]([CH2:35][CH3:36])[CH2:37][CH3:38])[s:24]1.[CH2:8]1[O:9][CH2:10][CH2:11][CH2:12]1.[CH3:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH3:1][c:2]1[s:3][cH:4][c:5]([CH3:7])[n:6]1.[CH3:42][CH2:43][O:44][C:45]([CH3:46])=[O:47]>>[CH3:1][c:2]1[s:3][c:4](-[c:20]2[cH:21][c:22]([CH3:41])[c:23](-[c:25]3[c:26]([CH3:40])[n:27][c:28]4[n:29]3[n:30][c:31]([CH3:39])[cH:32][c:33]4[CH:34]([CH2:35][CH3:36])[CH2:37][CH3:38])[s:24]2)[c:5]([CH3:7])[n:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8058HexaneHCID 8857Ethyl AcetateHCID 109342,4-DimethylthiazoleHCID 579329433-(5-Bromo-3-methyl-thiophen-2-yl)-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine

Product 1

HCID 579329943-[5-(2,4-Dimethyl-thiazol-5-yl)-3-methyl-thiophen-2-yl]-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine

Sources & evidence

ORD record
ord-b2cfb6d633d44826bd1f0b183adf567b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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