Dimethylformamide → 4-(3-Piperidin-1-yl-propionyl)-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-b]azepine-2-carbaldehyde

HRID 213635Notes

Reaction equation

HRID 213635 reaction equation
[N:1]1([CH2:7][CH2:8][C:9](=[O:10])[N:11]2[c:12]3[c:13]([nH:18][cH:19][cH:20]3)[CH2:14][CH2:15][CH2:16][CH2:17]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[O:26]=[CH:27][N:28]([CH3:29])[CH3:30].[P:21]([Cl:22])([Cl:23])([Cl:24])=[O:25]>>[N:1]1([CH2:7][CH2:8][C:9](=[O:10])[N:11]2[c:12]3[c:13]([nH:18][c:19]([CH:27]=[O:26])[cH:20]3)[CH2:14][CH2:15][CH2:16][CH2:17]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 225618943-piperidin-1-yl-1-(5,6,7,8-tetrahydro-1H-pyrrolo[3,2-b]azepin-4-yl)-propan-1-one

Product 1

HCID 225616984-(3-Piperidin-1-yl-propionyl)-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-b]azepine-2-carbaldehyde

Sources & evidence

ORD record
ord-9f0ca6c843ee4cd4903a4f7ebc1b1ae4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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