Tetrahydrofuran → 1-Hydroxy-3-(2-(methoxymethyl)-7-methyl-2H-indazol-5-yl)propan-2-yl 4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxylate

HRID 213654Notes

Reaction equation

HRID 213654 reaction equation
[BH4-:40].[Li+:41].[O:1]=[c:2]1[nH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[cH:10][c:11]1[CH:12]1[CH2:13][CH2:14][N:15]([C:18](=[O:19])[O:20][CH:21]([C:22](=[O:23])[O:24][CH3:25])[CH2:26][c:27]2[cH:28][c:29]3[cH:30][n:31]([CH2:37][O:38][CH3:39])[n:32][c:33]3[c:34]([CH3:36])[cH:35]2)[CH2:16][CH2:17]1.[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[O:1]=[c:2]1[nH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[cH:10][c:11]1[CH:12]1[CH2:13][CH2:14][N:15]([C:18](=[O:19])[O:20][CH:21]([CH2:22][OH:23])[CH2:26][c:27]2[cH:28][c:29]3[cH:30][n:31]([CH2:37][O:38][CH3:39])[n:32][c:33]3[c:34]([CH3:36])[cH:35]2)[CH2:16][CH2:17]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 28123BorohydrideHCID 28486Lithium ionHCID 68460933[1-methoxy-3-[2-(methoxymethyl)-7-methylindazol-5-yl]-1-oxopropan-2-yl] 4-(2-oxo-1H-quinolin-3-yl)piperidine-1-carboxylate

Product 1

HCID 690718601-Hydroxy-3-(2-(methoxymethyl)-7-methyl-2H-indazol-5-yl)propan-2-yl 4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-f91560ccc87e491e963998726b6fefa4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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