Tetrahydrofuran → 8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one

HRID 2138186Notes

Reaction equation

HRID 2138186 reaction equation
[CH2:26]([P:27]([CH2:28][CH2:29][CH2:30][CH3:31])[CH2:32][CH2:33][CH2:34][CH3:35])[CH2:36][CH2:37][CH3:38].[CH:16]([CH3:17])([CH3:18])[N:19]1[CH2:20][CH2:21][CH:22]([OH:25])[CH2:23][CH2:24]1.[N:39]([C:40]([N:41]1[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46]1)=[O:47])=[N:48][C:49]([N:50]1[CH2:51][CH2:52][CH2:53][CH2:54][CH2:55]1)=[O:56].[O:57]1[CH2:58][CH2:59][CH2:60][CH2:61]1.[OH:1][c:2]1[cH:3][c:4]2[cH:5][c:6]3[n:7]([c:8]2[cH:9][cH:10]1)[CH2:11][CH2:12][NH:13][C:14]3=[O:15]>>[O:1]([c:2]1[cH:3][c:4]2[cH:5][c:6]3[n:7]([c:8]2[cH:9][cH:10]1)[CH2:11][CH2:12][NH:13][C:14]3=[O:15])[CH:22]1[CH2:21][CH2:20][N:19]([CH:16]([CH3:17])[CH3:18])[CH2:24][CH2:23]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 13831TributylphosphineHCID 730421,1'-(Azodicarbonyl)dipiperidineHCID 796811-Isopropylpiperidin-4-olHCID 684650438-hydroxy-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

Product 1

HCID 166795188-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one

Sources & evidence

ORD record
ord-cb32dd355539480688325162de7ae433
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…