Bicarbonate Ion → tert-Butyl 4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

HRID 213875Notes

Reaction equation

HRID 213875 reaction equation
[CH3:14][CH2:15][N:16]([CH2:17][CH3:18])[CH2:19][CH3:20].[CH:1]([CH3:2])([CH3:3])[n:4]1[c:5](=[O:13])[nH:6][c:7]2[c:8]1[cH:9][cH:10][cH:11][cH:12]2.[NH2:21][CH2:22][CH:23]1[CH2:24][CH2:25][N:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:27][CH2:28]1.[Na+:40].[O-:36][C:37]([OH:38])=[O:39].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1>>[CH:1]([CH3:2])([CH3:3])[n:4]1[c:5](=[O:13])[n:6]([C:37]([NH:21][CH2:22][CH:23]2[CH2:24][CH2:25][N:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:27][CH2:28]2)=[O:36])[c:7]2[c:8]1[cH:9][cH:10][cH:11][cH:12]2

Participants

7

Reactant 6

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 7368171-Boc-4-(aminomethyl)piperidineHCID 16535801-(Propan-2-yl)-1,3-dihydro-2H-benzimidazol-2-one

Product 1

HCID 59428174tert-Butyl 4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-1548d242330c4ac29646e363a433d5fe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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