Bicarbonate Ion → 2-(4-Bromonaphthalen-2-ylmethyl)-5-fluorobenzo[b]thiophene

HRID 2139416Notes

Reaction equation

HRID 2139416 reaction equation
[B:13]([F:14])([F:15])[F:16].[Br:17][c:18]1[cH:19][c:20]([CH:28]([OH:29])[c:30]2[cH:31][c:32]3[c:33]([s:34]2)[cH:35][cH:36][c:37]([F:39])[cH:38]3)[cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]12.[C:40](=[O:41])([O-:42])[OH:43].[CH2:1]([SiH:2]([CH2:3][CH3:4])[CH2:5][CH3:6])[CH3:7].[CH2:45]([Cl:46])[Cl:47].[CH2:8]([O:9][CH2:10][CH3:11])[CH3:12].[Na+:44]>>[Br:17][c:18]1[cH:19][c:20]([CH2:28][c:30]2[cH:31][c:32]3[c:33]([s:34]2)[cH:35][cH:36][c:37]([F:39])[cH:38]3)[cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]12

Participants

8

Reactant 7

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 6356Boron trifluorideHCID 12052TriethylsilaneHCID 67156712(4-Bromo-naphthalen-2-yl)-(5-fluorobenzo[b]-thiophen-2-yl)methanol

Product 1

HCID 671565772-(4-Bromonaphthalen-2-ylmethyl)-5-fluorobenzo[b]thiophene

Sources & evidence

ORD record
ord-fa5e91d839b644a99a6e305777ccc4d1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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