Tetrahydrofuran → 1-(2,3,4-Trimethoxyphenyl)methyl-4-[(2-(4-trifluoromethylphenyl)-1,5-dimethylimidazol-4-yl)prop-1-yl]piperazine

HRID 2140636Notes

Reaction equation

HRID 2140636 reaction equation
[Al+3:2].[CH3:7][O:8][c:9]1[c:10]([CH2:19][N:20]2[CH2:21][CH2:22][N:23]([CH2:26][CH2:27][C:28](=[O:29])[c:30]3[n:31][c:32](-[c:37]4[cH:38][cH:39][c:40]([C:43]([F:44])([F:45])[F:46])[cH:41][cH:42]4)[n:33]([CH3:36])[c:34]3[CH3:35])[CH2:24][CH2:25]2)[cH:11][cH:12][c:13]([O:17][CH3:18])[c:14]1[O:15][CH3:16].[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3].[O:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1>>[CH3:7][O:8][c:9]1[c:10]([CH2:19][N:20]2[CH2:21][CH2:22][N:23]([CH2:26][CH2:27][CH2:28][c:30]3[n:31][c:32](-[c:37]4[cH:38][cH:39][c:40]([C:43]([F:44])([F:45])[F:46])[cH:41][cH:42]4)[n:33]([CH3:36])[c:34]3[CH3:35])[CH2:24][CH2:25]2)[cH:11][cH:12][c:13]([O:17][CH3:18])[c:14]1[O:15][CH3:16]

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 57152953HCID 57152953, compound

Product 1

HCID 158190381-(2,3,4-Trimethoxyphenyl)methyl-4-[(2-(4-trifluoromethylphenyl)-1,5-dimethylimidazol-4-yl)prop-1-yl]piperazine

Sources & evidence

ORD record
ord-6946684cd106484fa2b833da1ce01f09
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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