Tetrahydrofuran → 1,1,1-Trifluoro-3-[1-(5-fluoro-2-methoxyphenyl)cyclopropyl]propan-2-one
Reaction equation
[Al+3:26].[CH2:1]([O:2][C:3](=[O:4])[C:5]([C:6]([F:7])([F:8])[F:9])([OH:10])[CH2:11][C:12]1([c:15]2[c:16]([O:22][CH3:23])[cH:17][cH:18][c:19]([F:21])[cH:20]2)[CH2:13][CH2:14]1)[CH3:24].[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[H-:25].[H-:28].[H-:29].[H-:30].[Li+:27]>>[C:5]([C:6]([F:7])([F:8])[F:9])(=[O:10])[CH2:11][C:12]1([c:15]2[c:16]([O:22][CH3:23])[cH:17][cH:18][c:19]([F:21])[cH:20]2)[CH2:13][CH2:14]1Participants
6
Sources & evidence
- ORD record
- ord-074b68fd5f3b4778b98713fb8b6d9ca3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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