Ammonium → 4-(3-Chloro-phenyl)-2-(6-piperidin-1-ylmethyl-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

HRID 2141326Notes

Reaction equation

HRID 2141326 reaction equation
[C:33]([O:34][BH-:35]([O:36][C:37](=[O:38])[CH3:39])[O:40][C:41](=[O:42])[CH3:43])(=[O:44])[CH3:45].[C:49](=[O:50])([O-:51])[O-:52].[CH2:27]1[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]1.[Cl-:47].[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10](-[n:16]3[cH:17][n:18][c:19]4[c:20]3[cH:21][c:22]([CH:25]=[O:26])[cH:23][cH:24]4)[s:11][c:12]2[C:13](=[O:14])[NH2:15])[cH:5][cH:6][cH:7]1.[Cl:55][CH2:56][Cl:57].[K+:53].[K+:54].[NH4+:48].[Na+:46]>>[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10](-[n:16]3[cH:17][n:18][c:19]4[c:20]3[cH:21][c:22]([CH2:25][N:30]3[CH2:29][CH2:28][CH2:27][CH2:32][CH2:31]3)[cH:23][cH:24]4)[s:11][c:12]2[C:13](=[O:14])[NH2:15])[cH:5][cH:6][cH:7]1

Participants

10

Reactant 9

HCID 223AmmoniumHCID 312ChlorideHCID 813Potassium Cation2×HCID 923Sodium ionHCID 6344DichloromethaneHCID 8082PiperidineHCID 19660Carbonate IonHCID 2724942TriacetoxyborohydrideHCID 866428104-(3-Chloro-phenyl)-2-(6-formyl-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

Product 1

HCID 468349034-(3-Chloro-phenyl)-2-(6-piperidin-1-ylmethyl-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

Sources & evidence

ORD record
ord-7940627804ff4ecd97e635e434dbdba6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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