反应详情

tert-Butyldimethylsilylchloride (100 g, 0.66M) in dry dichloromethane (70 ml) was added, drop-wise, to a stirred mixture of distilled ethylene glycol (205.6 g, 3.31M), dry dichloromethane (200 ml), triethylamine (120 ml, 0.86M) and 4-dimethylaminopyridine (8 g, 0.066M) at 0° C. under a nitrogen atmosphere. After the addition the mixture was allowed to warm to ambient temperature and was stirred for a further 3 hours. The mixture was then filtered and the filtrate washed with dilute sodium bicarbonate solution, brine, dried over magnesium sulphate, filtered and then evaporated in vacuo to give a pale yellow oil.

1. additionAfter the addition the mixture
2. filtrationThe mixture was then filtered
3. washthe filtrate washed with dilute sodium bicarbonate solution, brine
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. customevaporated in vacuo
7. customto give a pale yellow oil