Tetrahydrofuran → tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
Reaction equation
[Al+3:21].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[F:1][C:2]1([C:15](=[O:16])[O:17][CH2:18][CH3:19])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1.[H-:20].[H-:23].[H-:24].[H-:25].[Li+:22]>>[F:1][C:2]1([CH2:15][OH:16])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1Participants
6
Sources & evidence
- ORD record
- ord-516c725c597f45ea902b61ef7c997a85
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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