Hydrogen Bromide → (+/-)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-pyridin-2-ylmethyl-1,2,3,4-tetrahydro-cyclopenta[b]indole-7-carbonitrile

HRID 2143617Notes

Reaction equation

HRID 2143617 reaction equation
[Br:33][CH2:34][c:35]1[n:36][cH:37][cH:38][cH:39][cH:40]1.[BrH:32].[C:26](=[O:27])([O-:28])[O-:29].[Cs+:30].[Cs+:31].[O:1]=[C:2]1[N:3]([CH:12]2[CH2:13][c:14]3[c:15]([nH:16][c:17]4[cH:18][cH:19][c:20]([C:23]#[N:24])[cH:21][c:22]34)[CH2:25]2)[C:4](=[O:11])[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21.[O:42]=[CH:43][N:44]([CH3:45])[CH3:46].[OH2:41]>>[O:1]=[C:2]1[N:3]([CH:12]2[CH2:13][c:14]3[c:15]([n:16]([CH2:34][c:35]4[n:36][cH:37][cH:38][cH:39][cH:40]4)[c:17]4[cH:18][cH:19][c:20]([C:23]#[N:24])[cH:21][c:22]34)[CH2:25]2)[C:4](=[O:11])[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21

Participants

8

Reactant 7

HCID 260Hydrogen BromideHCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 5642092-(Bromomethyl)pyridineHCID 581494122-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2,3,4-tetrahydrocyclopenta[b]indole-7-carbonitrile

Product 1

HCID 59242704(+/-)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-pyridin-2-ylmethyl-1,2,3,4-tetrahydro-cyclopenta[b]indole-7-carbonitrile

Sources & evidence

ORD record
ord-efac4256c7f245e7ac628c069b39c032
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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