Dimethyl Sulfoxide → 2-(2,6-Difluorophenyl)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)oxazole-4-carboxamide

HRID 2144028Notes

Reaction equation

HRID 2144028 reaction equation
[CH3:27][N:28]1[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]1.[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH3:41][S:42]([CH3:43])=[O:44].[Cl:1][CH2:2][CH2:3][O:4][c:5]1[cH:6][cH:7][c:8](-[c:11]2[c:12]([C:24](=[O:25])[NH2:26])[n:13][c:14](-[c:16]3[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]3[F:22])[o:15]2)[cH:9][cH:10]1>>[CH2:2]([CH2:3][O:4][c:5]1[cH:6][cH:7][c:8](-[c:11]2[c:12]([C:24](=[O:25])[NH2:26])[n:13][c:14](-[c:16]3[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]3[F:22])[o:15]2)[cH:9][cH:10]1)[N:31]1[CH2:30][CH2:29][N:28]([CH3:27])[CH2:33][CH2:32]1

Participants

5

Reactant 4

HCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 531671-MethylpiperazineHCID 595873755-(4-(2-Chloroethoxy)phenyl)-2-(2,6-difluorophenyl)oxazole-4-carboxamide

Product 1

HCID 595873882-(2,6-Difluorophenyl)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)oxazole-4-carboxamide

Sources & evidence

ORD record
ord-0c81aa7bd8dd455b8de8de4f5bcaca98
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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