Bicarbonate Ion → 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-(2-formyl-1-methyl-1H-imidazol-5-yl)thieno[3,2-b]pyridine-6-carbonitrile

HRID 2146130Notes

Reaction equation

HRID 2146130 reaction equation
[C:52](=[O:53])([OH:54])[O-:55].[CH2:57]1[O:58][CH2:59][CH2:60][O:61][CH2:62]1.[CH3:24][n:25]1[c:26]([CH:43]=[O:44])[n:27][cH:28][c:29]1[Sn:30]([CH2:31][CH2:32][CH2:33][CH3:34])([CH2:35][CH2:36][CH2:37][CH3:38])[CH2:39][CH2:40][CH2:41][CH3:42].[CH3:45][CH2:46][N:47]([CH2:48][CH3:49])[CH2:50][CH3:51].[Cl:1][c:2]1[c:3]([NH:11][c:12]2[c:13]3[c:14]([n:15][cH:16][c:17]2[C:18]#[N:19])[cH:20][c:21]([I:23])[s:22]3)[cH:4][c:5]([O:9][CH3:10])[c:6]([Cl:8])[cH:7]1.[Na+:56].[Pd:63]([Cl:64])[Cl:65].[c:66]1([P:67]([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)[cH:80][cH:81][cH:82][cH:83][cH:84]1.[c:85]1([P:86]([c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)[c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)[cH:99][cH:100][cH:101][cH:102][cH:103]1>>[Cl:1][c:2]1[c:3]([NH:11][c:12]2[c:13]3[c:14]([n:15][cH:16][c:17]2[C:18]#[N:19])[cH:20][c:21](-[c:29]2[n:25]([CH3:24])[c:26]([CH:43]=[O:44])[n:27][cH:28]2)[s:22]3)[cH:4][c:5]([O:9][CH3:10])[c:6]([Cl:8])[cH:7]1

Participants

9

Reactant 8

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 312751,4-DioxaneHCID 103902087-[(2,4-Dichloro-5-methoxyphenyl)amino]-2-iodothieno[3,2-b]pyridine-6-carbonitrileHCID 222566721-methyl-5-(tributylstannyl)-1H-imidazole-2-carbaldehyde

Product 1

HCID 100043027-[(2,4-dichloro-5-methoxyphenyl)amino]-2-(2-formyl-1-methyl-1H-imidazol-5-yl)thieno[3,2-b]pyridine-6-carbonitrile

Sources & evidence

ORD record
ord-c4baff8f9f72490b8bb1d18e01e78823
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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