Tetrahydrofuran → 2-(2,4-dimethoxybenzyl)-5-morpholin-4-ylmethyl-2,3-dihydro-1H-isoindole

HRID 2146576Notes

Reaction equation

HRID 2146576 reaction equation
[Al+3:30].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:1][O:2][c:3]1[c:4]([CH2:5][N:6]2[CH2:7][c:8]3[cH:9][cH:10][c:11]([C:15](=[O:16])[N:17]4[CH2:18][CH2:19][O:20][CH2:21][CH2:22]4)[cH:12][c:13]3[CH2:14]2)[cH:23][cH:24][c:25]([O:27][CH3:28])[cH:26]1.[H-:29].[H-:32].[H-:33].[H-:34].[Li+:31]>>[CH3:1][O:2][c:3]1[c:4]([CH2:5][N:6]2[CH2:7][c:8]3[cH:9][cH:10][c:11]([CH2:15][N:17]4[CH2:18][CH2:19][O:20][CH2:21][CH2:22]4)[cH:12][c:13]3[CH2:14]2)[cH:23][cH:24][c:25]([O:27][CH3:28])[cH:26]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 59006996HCID 59006996, compound

Product 1

HCID 666723362-(2,4-dimethoxybenzyl)-5-morpholin-4-ylmethyl-2,3-dihydro-1H-isoindole

Sources & evidence

ORD record
ord-fd318bd17e8e4c1a9ffdc58bc7a2f3ca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…