Toluene → 2-[1-(2-chlorophenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-4-(methanesulfonamido)-N-(5-methyl-2-pyridinyl)butanamide

HRID 214687Notes

Reaction equation

HRID 214687 reaction equation
[CH3:1][Al:2]([CH3:3])[CH3:4].[CH3:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1.[CH3:5][c:6]1[cH:7][cH:8][c:9]([NH2:12])[n:10][cH:11]1.[Cl:13][c:14]1[c:15](-[n:20]2[n:21][cH:22][c:23]3[c:24]2[n:25][cH:26][n:27][c:28]3[O:29][CH:30]2[C:31](=[O:39])[N:32]([S:35](=[O:36])(=[O:37])[CH3:38])[CH2:33][CH2:34]2)[cH:16][cH:17][cH:18][cH:19]1>>[CH3:5][c:6]1[cH:7][cH:8][c:9]([NH:12][C:31]([CH:30]([O:29][c:28]2[c:23]3[cH:22][n:21][n:20](-[c:15]4[c:14]([Cl:13])[cH:19][cH:18][cH:17][cH:16]4)[c:24]3[n:25][cH:26][n:27]2)[CH2:34][CH2:33][NH:32][S:35](=[O:36])(=[O:37])[CH3:38])=[O:39])[n:10][cH:11]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 153482-Amino-5-methylpyridineHCID 16682925TrimethylaluminumHCID 765504753-[1-(2-Chlorophenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-1-methylsulfonylpyrrolidin-2-one

Product 1

HCID 765503862-[1-(2-chlorophenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-4-(methanesulfonamido)-N-(5-methyl-2-pyridinyl)butanamide

Sources & evidence

ORD record
ord-ae370b4110224eabb9613f18905367c7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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