1-Butanol → (2R)-2-(2,5-difluorophenyl)-1-{pyrazolo[1,5-a]pyrimidin-5-yl}pyrrolidine
Reaction equation
[CH2:24]([OH:25])[CH2:26][CH2:27][CH3:28].[CH3:38][CH2:39][O:40][C:41]([CH3:42])=[O:43].[CH:29]([N:30]([CH2:31][CH3:32])[CH:33]([CH3:34])[CH3:35])([CH3:36])[CH3:37].[Cl:1][c:2]1[n:3][c:4]2[n:5]([cH:6][cH:7]1)[n:8][cH:9][cH:10]2.[F:11][c:12]1[c:13]([CH:19]2[NH:20][CH2:21][CH2:22][CH2:23]2)[cH:14][c:15]([F:18])[cH:16][cH:17]1>>[c:2]1([N:20]2[CH:19]([c:13]3[c:12]([F:11])[cH:17][cH:16][c:15]([F:18])[cH:14]3)[CH2:23][CH2:22][CH2:21]2)[n:3][c:4]2[n:5]([cH:6][cH:7]1)[n:8][cH:9][cH:10]2Participants
6
Sources & evidence
- ORD record
- ord-f5e5b98a86e64b02b540ce85e2890a70
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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