Methanol → rac-(2'S,3'S,4'S)-6-chloro-2'-(3-chloro-2-fluoro-phenyl)-4'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid 4-carboxy-phenyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([O:11][C:12](=[O:13])[N:14]2[CH:15]([c:34]3[c:35]([F:41])[c:36]([Cl:40])[cH:37][cH:38][cH:39]3)[C:16]3([C:17](=[O:26])[NH:18][c:19]4[cH:20][c:21]([Cl:25])[cH:22][cH:23][c:24]43)[CH:27]([CH2:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:28]2)[cH:9][cH:10]1.[CH3:44][OH:45].[Li+:43].[O:46]1[CH2:47][CH2:48][CH2:49][CH2:50]1.[OH-:42].[OH2:51]>>[O:2]=[C:3]([OH:4])[c:5]1[cH:6][cH:7][c:8]([O:11][C:12](=[O:13])[N:14]2[CH:15]([c:34]3[c:35]([F:41])[c:36]([Cl:40])[cH:37][cH:38][cH:39]3)[C:16]3([C:17](=[O:26])[NH:18][c:19]4[cH:20][c:21]([Cl:25])[cH:22][cH:23][c:24]43)[CH:27]([CH2:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:28]2)[cH:9][cH:10]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-1378d80fa62642f295f8c798255bc0b8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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