Acetic Acid → (9-((5-(2-(Tert-butyldimethylsilyloxy)ethyl)thiophen-3-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

HRID 2148555Notes

Reaction equation

HRID 2148555 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][c:9]1[cH:10][c:11]([CH:14]=[O:15])[cH:12][s:13]1)([CH3:16])[CH3:17].[C:46]([O:47][BH-:48]([O:49][C:50](=[O:51])[CH3:52])[O:53][C:54](=[O:55])[CH3:56])(=[O:57])[CH3:58].[C:60](=[O:61])([OH:62])[O-:63].[CH3:65][N:66]1[CH2:67][CH2:68][CH2:69][C:70]1=[O:71].[CH3:72][C:73](=[O:74])[OH:75].[CH:25]([CH3:26])([CH3:27])[c:28]1[s:29][cH:30][c:31]([C:33](=[O:34])[N:35]2[CH2:36][CH2:37][O:38][C:39]3([CH2:40]2)[CH2:41][CH2:42][NH:43][CH2:44][CH2:45]3)[n:32]1.[F:18][C:19]([F:20])([F:21])[C:22]([OH:23])=[O:24].[Na+:59].[Na+:64].[OH2:76]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][c:9]1[cH:10][c:11]([CH2:14][N:43]2[CH2:42][CH2:41][C:39]3([O:38][CH2:37][CH2:36][N:35]([C:33]([c:31]4[cH:30][s:29][c:28]([CH:25]([CH3:26])[CH3:27])[n:32]4)=[O:34])[CH2:40]3)[CH2:45][CH2:44]2)[cH:12][s:13]1)([CH3:16])[CH3:17]

Participants

10

Reactant 9

HCID 176Acetic AcidHCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 962WaterHCID 6422Trifluoroacetic acidHCID 13387N-methyl-2-pyrrolidoneHCID 2724942TriacetoxyborohydrideHCID 579889035-(2-(Tert-butyldimethylsilyloxy)ethyl)thiophene-3-carbaldehydeHCID 57989152(2-Isopropylthiazol-4-yl)-(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

Product 1

HCID 57988978(9-((5-(2-(Tert-butyldimethylsilyloxy)ethyl)thiophen-3-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Sources & evidence

ORD record
ord-9a8aed0dd3db4b67b09a6919fcc9a356
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…